Lomotil in acute diarrhoea.

Lomotil in diarrhoeal illnesses.

Sir, The article by Curtis and Goel (Archives, 1979, 54, 222) prompts me to place the usage of Lomotil in young children in the tropics in its right perspective. The problems of diarrhoea in the tropics are quite different when compared with temperate climates, and management of this condition is therefore also different. In situations where children have little or no access to optimal therapeu...

Acute diarrhoea in adults

Firstly, the planners, the economists, the actuaries, and the lawyers have to sit down with tne doctors and devise a new format, shorn of expensive bureaucracy, which is more efficient, competitive, and, in the long run, cheaper. This then has to be sold up-hill to those who will fear losing their mess of pottage in any transition, and this would obviously mean many of the senior doctors approa...

Lomotil in diarrhoeal illnesses.

Lomotil poisoning in children.

45 children were admitted to hospital after ingesting varying quantities of diphenoxylate (Lomotil). One died and 44 recovered without any sequelae. Four patients were comatose, 32 were drowsy, and 9 suffered respiratory depression. No correlation was found between ingested dose and the severity of symptoms. Because of its action in rendering the gut atonic, removal of diphenoxylate by gastric ...

Gut hormones in acute diarrhoea.

The gut hormone response to a breakfast meal was studied in 12 subjects hospitalised for an episode of acute diarrhoea (presumed infective) who were otherwise well and in 13 healthy control subjects. Fasting blood glucose concentrations were low but basal insulin concentrations were raised. Basal concentrations of pancreatic polypeptide and both basal and postprandial responses of motilin, ente...